Products for Research Use Only
RegisterLogin

HDAC3-IN-5

CAT: 0804-HY-162769Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-162769Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HDAC3-IN-5 (9c) is a HDAC3 selective inhibitor, with IC50 values of 4.2 nM, 1629 nM and 298.2 nM for HDAC3, HDAC2, HDAC1, respectively. HDAC3-IN-5 (9c) can effectively induce apoptosisin MV4-11 cells in vitro and reduce the expression of anti-apoptotic proteins, the development of HDAC3 selective inhibitors may serve as a potential lead compound to reverse Venetoclax resistance[1].
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac3-in-5.html
Smiles
O=C(NNCCC)/C=C/C1=CC=C(CN(CCCC)CCC2=C(C)NC3=C2C=CC=C3)C=C1
Molecular Formula
C28H38N4O
Molecular Weight
446.63
References & Citations
[1]Enqiang Liu, et al. Design, synthesis, and biological activity evaluation of novel HDAC3 selective inhibitors for combination with Venetoclax against acute myeloid leukemia. Eur J Med Chem. 2024 Oct 5:276:116663.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3

Related Products

CatalogName
HY-172891CDK9/HDAC1/HDAC3-IN-1
HY-172133HDAC3-IN-6
HY-156096-01HDAC3-IN-2
HY-161154HDAC3-IN-3
HY-117374-01HDAC3-IN-1
HY-172601HDAC3-IN-7
HY-123295-01HDAC3-IN-T247
HY-159172HDAC3-IN-4
HY-179682HDAC3 degrader-1
HY-133147HDAC3/6-IN-2

Alternative Products

CatalogName
GTR19238265-01HDAC3-IN-5
482592HDAC3
bs-10024R-Cy5.5HDAC3 Polyclonal Antibody, Cy5.5 Conjugated
GTR17840654HDAC3 Rabbit Polyclonal Antibody (Cy5.5)
BA4136-25HDAC3-IN-T247
10R-2004HDAC3 antibody

Popular Products