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HDAC3 Inhibitor

CAT: 0931-T36575-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T36575-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2044701-99-5
Target
HDAC, Others
Related Pathways
Others, Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3; Ki = 0.16 nM) . It is selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95, 11.81, and 95.45 nM, respectively, using recombinant HDACs) . In addition, it is selective for acute myeloid, monocytic, and lymphoblastic leukemia cell lines (EC50s = 36.37, 76.64, and 151.7 nM, respectively) over chronic myeloid, acute promyelocytic, and acute lymphoblastic cells (EC50s = 2,160, >10,000, and >10,000 nM, respectively) .
Smiles
C(NNCCC)(=O)C1=CC=C(CNC(/C=C/C2=CC=CC=C2)=O)C=C1
Molecular Formula
C20H23N3O2
Molecular Weight
337.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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