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HDAC3-IN-6

CAT: 0804-HY-172133Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172133Size:1 Each
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Description
HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. HDAC3-IN-6 dose-dependently induces the expression of PD-L1. HDAC3-IN-6 induces more pronounced Apoptosis and production of ROS. HDAC3-IN-6 exhibits high antitumor efficacy against colorectal cancer[1].
CAS Number
3070532-72-5
UNSPSC
12352005
Target
Apoptosis; HDAC; PD-1/PD-L1; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(C1=CC=C(CNC(C2=CN=C(C3=CC=C4OC=CC4=C3)N2)=O)C=C1)NNCCC
Molecular Formula
C23H23N5O3
Molecular Weight
417.46
References & Citations
[1]Sun Z, et al. Discovery of Novel Hydrazide-Based HDAC3 Inhibitors as Epigenetic Immunomodulators for Cancer Immunotherapy. J Med Chem. 2025 Feb 13;68 (3) :3048-3064.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC3

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