HDAC3-IN-7

CAT: 0804-HY-172601Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172601Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC3-IN-7 (Compound 8ae) is a selective HDAC3 inhibitor with an IC50 value of 311 nM. HDAC3-IN-7 degrades PD-L1 through the lysosome pathway mediated by Cathepsin B, exerting activities such as inhibiting tumor cell proliferation, migration, and invasion. HDAC3-IN-7 is promising for research of cancers[1].
UNSPSC
12352211
Target
HDAC; PD-1/PD-L1
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NNCCC)CCCCCCNC(C1=CN=C(C2=CC=C(NC(OC(C)(C)C)=O)C=C2)S1)=O
Molecular Formula
C25H37N5O4S
Molecular Weight
503.66
References & Citations
[1]Hu Z, et al. Design, synthesis and bioevaluation of novel hydrazide derivatives as enhancers of immunotherapy and DNA-damage response in antitumor therapy. Eur J Med Chem. 2025 Apr 7;291:117601.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC3

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