PD-1/PD-L1-IN-54

PD-1/PD-L1-IN-54

• CAS Number: 1393644-68-2
• UNSPSC Description: PD-1/PD-L1-IN-54 (Compound 6) is a moderately affinic PD-1/PD-L1 inhibitor (KD: PD-1, 55.8 μM; PD-L1, 46.4 μM; IC50: 88.6 μM). PD-1/PD-L1-IN-54 inhibits PD-1/PD-L1 interactions and shows anticancer activity by activating CD8+ T cells, upregulating PD-1 expression, and increasing secretion of IFN-γ and IL-2. PD-1/PD-L1-IN-54 inhibits cancer cell proliferation and promotes apoptosis. PD-1/PD-L1-IN-54 also regulates T cell immunity through the PI3K/Akt pathway correlated with PD-1/PD-L1[1].
• Target Antigen: Akt; IFNAR; Interleukin Related; PD-1/PD-L1; PI3K
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pd-1-pd-l1-in-54.html
• Smiles: COC1=CC(O)=C(C(OC)=O)C(OC2=C(C)C=C(O)C=C2OC)=C1Cl
• Molecular Weight: 368.77
• References & Citations: [1]Kuang QX, et al. New benzophenone analogs from Nigrospora sphaerica and their inhibitory activity against PD-1/PD-L1 interactions. Bioorganic chemistry, 2024, 153, 107899.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported