PD-1/PD-L1-IN-34

PD-1/PD-L1-IN-34

• CAS Number: 2924403-17-6
• UNSPSC Description: PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) inhibits PD-1/PD-L1 interaction (IC50=0.029 μM), with a selected binding affinity with PD-L1 (KD=0.1554 μM). PD-1/PD-L1-IN-34 inhibits tumor growth by activating the immune microenvironment[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/pd-1-pd-l1-in-34.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C([C@@H]2[C@@H](C3=CC(OCC4=CC=CC(C#N)=C4)=C(C=C3Cl)CNC(C)(C(O)=O)C)C2)C=CC=C1C5=CC=CC=C5
• Molecular Weight: 565.10
• References & Citations: [1]Jing T, et al. Discovery and Optimization of Novel Biphenyl Derivatives Bearing Cyclopropyl Linkage as Potent Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Inhibitors. J Med Chem. 2023 May 25;66(10):6811-6835.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported