PD-1/PD-L1-IN-32

PD-1/PD-L1-IN-32

• CAS Number: 2765535-21-3
• UNSPSC Description: PD-1/PD-L1-IN-32 (compound A56) is a potent PD-1/PD-L1 inhibitor (IC50=2.4 nM), with anticancer activity. PD-1/PD-L1-IN-32 significantly inhibits tumor growth in hPD-L1 MC38 humanized mouse model, without obvious toxicity against mouse normal ability[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/pd-1-pd-l1-in-32.html
• Solubility: 10 mM in DMSO
• Smiles: N#CC1=CC(COC2=C(C=CC(OCC3=C(C(C4=CC=CC=C4F)=CC=C3)Cl)=C2)CNCCO)=CN=C1
• Molecular Weight: 517.98
• References & Citations: [1]Zhang H, et al. Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors. J Med Chem. 2023 Aug 10;66(15):10579-10603.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported