PD-1/PD-L1-IN-17

• UNSPSC Description:

  PD-1/PD-L1-IN-17 (Compound P20) is a potent inhibitor of PD-1/PD-L1 with an IC50 value of 26.8 nM. PD-1/PD-L1-IN-17 is a promising lead compound for the development of inhibitors of the PD-1/PD-L1 interaction. PD-1/PD-L1-IN-17 has the potential for the research of cancer diseases[1].

• Target Antigen:

  PD-1/PD-L1

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pd-1-pd-l1-in-17.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@H](CO)NCC1=CC2=C(ON=C2NC3=CC=CC(C4=CC=CC=C4)=C3Cl)C=C1)O

• Molecular Weight:

  437.88

• References & Citations:

  [1]Huang X, et al. Design, synthesis, and structure-activity relationship of PD-1/PD-L1 inhibitors with a benzo[d]isoxazole scaffold. Bioorg Med Chem Lett. 2021 Nov 15;52:128403.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2851938-36-6