PD-1/PD-L1-IN-17

PD-1/PD-L1-IN-17

• CAS Number: 2851938-36-6
• UNSPSC Description: PD-1/PD-L1-IN-17 (Compound P20) is a potent inhibitor of PD-1/PD-L1 with an IC50 value of 26.8 nM. PD-1/PD-L1-IN-17 is a promising lead compound for the development of inhibitors of the PD-1/PD-L1 interaction. PD-1/PD-L1-IN-17 has the potential for the research of cancer diseases[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pd-1-pd-l1-in-17.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@H](CO)NCC1=CC2=C(ON=C2NC3=CC=CC(C4=CC=CC=C4)=C3Cl)C=C1)O
• Molecular Weight: 437.88
• References & Citations: [1]Huang X, et al. Design, synthesis, and structure-activity relationship of PD-1/PD-L1 inhibitors with a benzo[d]isoxazole scaffold. Bioorg Med Chem Lett. 2021 Nov 15;52:128403.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported