PD-1/PD-L1-IN-51

PD-1/PD-L1-IN-51

• UNSPSC Description: PD-1/PD-L1-IN-51 (Compound III-4) is a PD-1/PD-L1 inhibitor (IC50: 2.9 nM for hPD-L1). PD-1/PD-L1-IN-51 directly binds to PD-L1 to block the interaction between PD-1/PD-L1 and enhances IFN-γ release. PD-1/PD-L1-IN-51 has tumor inhibitory activity[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/pd-1-pd-l1-in-51.html
• Smiles: OC[C@H](C(O)=O)NCC1=CC(Cl)=C(OCC2=C(C)C(C3=CC=CC(OCCCN4N=NC(CN[C@@H](C(O)=O)CO)=C4)=C3C)=CC=C2)C=C1OCC5=CC(C#N)=CN=C5
• Molecular Weight: 814.28
• References & Citations: [1]Xia Y,et al. Design, synthesis, and antitumor activity evaluation of 1,2,3-triazole derivatives as potent PD-1/PD-L1 inhibitors. Bioorg Chem. 2024 Sep 7;153:107813.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported