Apoptosis inducer 34

CAT: 0804-HY-116692-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-116692-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Apoptosis inducer 34 (Compound 4) is a small molecule compound that induces apoptosis by directly activating the intrinsic apoptotic pathway. Apoptosis inducer 34 promotes Apaf-1 oligomerization to form mature apoptosomes, thereby activating caspase-9 and caspase-3. It significantly activates the apoptotic pathway in Jurkat cells by enhancing the cytochrome c-dependent apoptotic signaling pathway, inducing PARP cleavage and chromosomal DNA fragmentation. Furthermore, Apoptosis inducer 34 exhibits low toxicity to normal cells, demonstrating potential for selective targeting of cancer cells. Apoptosis inducer 34 is a promising candidate for studying cancer related to apoptotic pathways[1].
CAS Number
[582314-48-5]
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Apoptosis; Caspase; DNA/RNA Synthesis; Mitochondrial Metabolism; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apoptosis-inducer-34.html
Smiles
O=C(O[C@H]1CCC2=C1C=CC=C2)NCC3=CC=C(Cl)C(Cl)=C3
Molecular Formula
C17H15Cl2NO2
Molecular Weight
336.21
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Nguyen JT, et al. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc Natl Acad Sci U S A. 2003 Jun 24;100 (13) :7533-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-168927Apoptosis inducer 36
HY-163893Apoptosis inducer 23
HY-N10417Apoptosis inducer 5
HY-161814Apoptosis inducer 20
HY-172595Apoptosis inducer 48
HY-161473Apoptosis inducer 16
HY-147822Apoptosis inducer 6
HY-169124Apoptosis inducer 28
HY-163924Apoptosis inducer 25
HY-146092Apoptosis inducer 4

Alternative Products

CatalogName
TBI2950-100UGApoptolidin, Apoptosis inducer
MF-0119342-01Apoptosis inducer 42
MF-0118836-01Apoptosis inducer 39
MF-0117363-01Apoptosis inducer 18
MF-0116926-01Apoptosis inducer 15
MF-0116340-01Apoptosis inducer 14
MF-0113341-01Apoptosis inducer 31
MF-0112322-01Apoptosis inducer 32
MF-0110549-01Apoptosis inducer 29
MF-0122282-01Apoptosis inducer 22

Popular Products