Apoptosis inducer 43

• Description:

  Apoptosis inducer 43 is an apoptosis inducer. Apoptosis inducer 43 can induce apoptosis, SubG0-G1 cell cycle arrest, secondary necrosis, and upregulate caspase-3, p53, and Bax/Bcl-2 expression in HCT116 cells. Apoptosis inducer 43 can inhibit tumor growth in a solid Ehrlich carcinoma (SEC) mouse model. Apoptosis inducer 43 can be used to study cancers such as colon cancer, leukemia, and non-small cell lung cancer[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Bcl-2 Family; Caspase; MDM-2/p53

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  O=C(NC1=CC=CC(C(/C=C/C2=CC=C(C3=CC=CC=C3)C=C2)=O)=C1)C([NH3+])CC4=CC=CC=C4.FC(F)(F)C([O-])=O

• Molecular Formula:

  C32H27F3N2O4

• Molecular Weight:

  560.56

• References & Citations:

  [1]El-Haggar R, et al.. Amino acid-modified chalcone derivatives with in vitro and in vivo efficacy against colon cancer. Eur J Med Chem. 2025 Nov 5;297:117963. https://pubmed.ncbi.nlm.nih.gov/40695035/

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Bax; Bcl-2; Caspase 3