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Apoptosis inducer 49

CAT: 0804-HY-178940Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178940Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Apoptosis inducer 49 is a selective apoptosis inducer with high specificity against CCRF-CEM leukemia cells (IC50 = 2.68 μM) . Apoptosis inducer 49 enhances RNA synthesis and replication stress, activates the Chk1-p21 axis, leading to S-phase arrest. Apoptosis inducer 49 can inhibit Bcl-2 and activate caspase-3. Apoptosis inducer 49 can be used for the study of Leukemia[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; CDK; Checkpoint Kinase (Chk) ; DNA/RNA Synthesis
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC[C@]4([H])[C@@]5([H])[C@H](C(C6=CN(CC7=CC=CO7)N=N6)=C)CC[C@@](CO)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
Molecular Formula
C36H53N3O3
Molecular Weight
575.82
References & Citations
[1]Orság Š, et al. Synthesis and biological evaluation of novel C-30 modified lupane triterpenoids selectively cytotoxic against cancer cells. Eur J Med Chem. 2025 Oct 16;302 (Pt 1) :118268.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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