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Apoptosis inducer 36

CAT: 0804-HY-168927Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168927Size:1 Each
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Description
Apoptosis inducer 36 (Compound 42) exhibits anti-leukemic activity through reduction of leukemia stem cells (LSCs) and induction of differentiation. Apoptosis inducer 36 inhibits the proliferation of AML cells, arrests cell cycle at G1 phase, and induces PANoptosis including apoptosis, pyroptosis and necrosis. Prodrug of apoptosis inducer 36 exhibits orally active antitumor efficacy in mouse model[1].
CAS Number
2831492-41-0
UNSPSC
12352211
Target
Apoptosis; Pyroptosis
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Cancer
Smiles
[H][C@@]12CC(C(O[C@@H]1CC[C@@]3([C@H](CC[C@]32[H])O[Si](C(C)C)(C(C)C)C(C)C)C)=O)=C
Molecular Formula
C23H40O3Si
Molecular Weight
392.65
References & Citations
[1]Wang J, et al., Discovery of novel sitolactone derivative leading to PANoptosis and differentiation of acute myeloid leukemia cells. Eur J Med Chem. 2025 Feb 12;288:117360.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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