Apoptosis inducer 36

• Description :

  Apoptosis inducer 36 (Compound 42) exhibits anti-leukemic activity through reduction of leukemia stem cells (LSCs) and induction of differentiation. Apoptosis inducer 36 inhibits the proliferation of AML cells, arrests cell cycle at G1 phase, and induces PANoptosis including apoptosis, pyroptosis and necrosis. Prodrug of apoptosis inducer 36 exhibits orally active antitumor efficacy in mouse model[1].

• UNSPSC :

  12352211

• Target :

  Apoptosis; Pyroptosis

• Related Pathways :

  Apoptosis; Immunology/Inflammation

• Field of Research :

  Cancer

• Smiles :

  [H][C@@]12CC(C(O[C@@H]1CC[C@@]3([C@H](CC[C@]32[H])O[Si](C(C)C)(C(C)C)C(C)C)C)=O)=C

• Molecular Formula :

  C23H40O3Si

• Molecular Weight :

  392.65

• References & Citations :

  [1]Wang J, et al., Discovery of novel sitolactone derivative leading to PANoptosis and differentiation of acute myeloid leukemia cells. Eur J Med Chem. 2025 Feb 12;288:117360.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2831492-41-0]