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Apoptosis inducer 45

CAT: 0804-HY-178099Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178099Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Apoptosis inducer 45 is an apoptosis inducer. Apoptosis inducer 45 is cytotoxically active against the MCF-7 cell line. Apoptosis inducer 45 elicits MCF-7 cell apoptosis via the mitochondrial pathway (increases the Bax/Bcl-2 ratio) by activating cleavage of caspase-9, thereby inducing the fragmentation of DNA repair protein PARP. Apoptosis inducer 45 also can induce caspase-8 cleavage, subsequently initiating cleavage of caspase-3 and its downstream protein PARP to culminate in the extrinsic apoptosis. Apoptosis inducer 45 can be used in the research of breast cancer[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
[H][C@]1(C(CC[C@@]2(C(C)([C@@H](CC[C@@]12C)O)C)[H])=C)CC/C(C)=C/C(N3CCN(CC3)CC4=CC=C(C=C4)C(NCCC5=CC=C(C=C5)C)=O)=O
Molecular Formula
C41H57N3O3
Molecular Weight
639.91
References & Citations
[1]Wang X, et al. Structural hybridization of alepterolic acid with piperazine-benzamide motifs yields potent anticancer agents. Bioorg Chem. 2025 Sep 4;165:108931.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Caspase 3; Caspase 8; Caspase 9; PARP

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