Apoptosis inducer 45

• Description :

  Apoptosis inducer 45 is an apoptosis inducer. Apoptosis inducer 45 is cytotoxically active against the MCF-7 cell line. Apoptosis inducer 45 elicits MCF-7 cell apoptosis via the mitochondrial pathway (increases the Bax/Bcl-2 ratio) by activating cleavage of caspase-9, thereby inducing the fragmentation of DNA repair protein PARP. Apoptosis inducer 45 also can induce caspase-8 cleavage, subsequently initiating cleavage of caspase-3 and its downstream protein PARP to culminate in the extrinsic apoptosis. Apoptosis inducer 45 can be used in the research of breast cancer[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Bcl-2 Family; Caspase; PARP

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics

• Field of Research :

  Cancer

• Smiles :

  [H][C@]1(C(CC[C@@]2(C(C)([C@@H](CC[C@@]12C)O)C)[H])=C)CC/C(C)=C/C(N3CCN(CC3)CC4=CC=C(C=C4)C(NCCC5=CC=C(C=C5)C)=O)=O

• Molecular Formula :

  C41H57N3O3

• Molecular Weight :

  639.91

• References & Citations :

  [1]Wang X, et al. Structural hybridization of alepterolic acid with piperazine-benzamide motifs yields potent anticancer agents. Bioorg Chem. 2025 Sep 4;165:108931.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Bax; Bcl-2; Caspase 3; Caspase 8; Caspase 9; PARP