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Apoptosis inducer 50

CAT: 0804-HY-179052Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179052Size:1 Each
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Description
Apoptosis inducer 50 (Compound 5e) is an apoptosis inducer as well as an autophagy inducer agent. Apoptosis inducer 50 exhibits potent and selective anti-cancer activity against triple-negative breast cancer cells and metastatic colon cancer cells. Apoptosis inducer 50 upregulates the expression of pro-apoptotic proteins (Bax, Bim, cleaved Caspase-9) and downregulates the expression of the anti-apoptotic protein (BCL-XL) . Apoptosis inducer 50 upregulates key autophagy markers such as Beclin-1 and ATG5, and enhances the conversion of LC3-I to LC3-II., Apoptosis inducer 50 arrests cancer cells in the G1/S phase by upregulating the expression of p21 and p27 while downregulating Cyclin D1. Apoptosis inducer 50 increases the level of ROS[1].
UNSPSC
12352005
Target
Apoptosis; Atg7; Atg8/LC3; Autophagy; Bcl-2 Family; Caspase; CDK; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
OC1=CC=CC=C1C2=NC(C3=CC=CC=C3O)=NN2C4=CC=C(C(N/N=C/C5=CC(/N=N/C6=CC=C([N+]([O-])=O)C=C6)=CC=C5O)=O)C=C4
Molecular Formula
C34H24N8O6
Molecular Weight
640.60
References & Citations
[1]Dilek Ö, et al. Structure-activity optimization of Deferasirox-derived aroyl hydrazones: Synthesis, DFT characterization, and mechanistic insights into selective anticancer activity against colon and breast cancer. Bioorg Chem. 2025 Oct;165:109061.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-xL; Bim; Caspase 9; CDK1

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