Apoptosis inducer 50

• Description:

  Apoptosis inducer 50 (Compound 5e) is an apoptosis inducer as well as an autophagy inducer agent. Apoptosis inducer 50 exhibits potent and selective anti-cancer activity against triple-negative breast cancer cells and metastatic colon cancer cells. Apoptosis inducer 50 upregulates the expression of pro-apoptotic proteins (Bax, Bim, cleaved Caspase-9) and downregulates the expression of the anti-apoptotic protein (BCL-XL) . Apoptosis inducer 50 upregulates key autophagy markers such as Beclin-1 and ATG5, and enhances the conversion of LC3-I to LC3-II., Apoptosis inducer 50 arrests cancer cells in the G1/S phase by upregulating the expression of p21 and p27 while downregulating Cyclin D1. Apoptosis inducer 50 increases the level of ROS[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Atg7; Atg8/LC3; Autophagy; Bcl-2 Family; Caspase; CDK; Reactive Oxygen Species (ROS)

• Related Pathways:

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research:

  Cancer

• Smiles:

  OC1=CC=CC=C1C2=NC (C3=CC=CC=C3O) =NN2C4=CC=C (C (N/N=C/C5=CC (/N=N/C6=CC=C ([N+] ([O-]) =O) C=C6) =CC=C5O) =O) C=C4

• Molecular Formula:

  C34H24N8O6

• Molecular Weight:

  640.60

• References & Citations:

  [1]Dilek Ö, et al. Structure-activity optimization of Deferasirox-derived aroyl hydrazones: Synthesis, DFT characterization, and mechanistic insights into selective anticancer activity against colon and breast cancer. Bioorg Chem. 2025 Oct;165:109061.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Bax; Bcl-xL; Bim; Caspase 9; CDK1