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Human IL-1β Protein

CAT: 0749-PRP1019-01Size: 5 µgDry Ice: NoHazardous: No
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CAT#:0749-PRP1019-01Size:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interleukin-1β (IL-1β or IL-1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL-1β is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE) . IL-1β is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by Interleukin 1β in the central nervous system (CNS) . IL-1β gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Description
Human IL-1β protein, expressed in E. coli
Product Name Alternative
IL-1; IL-1 beta; IL-1B; IL1-BETA; IL1F2; Interleukin-1 beta; IL1B
Gene ID
3553
Accession Number
P01584
Tag
IL-1β
Type
Cytokines and proteins
Applications
No tag
Purity
> 98 % as determined by SDS-PAGE
Activity
Immobilized human IL-1β at 5 μg/mL (100 μl/well) can bind Human IL-1R1 with a linear range of 3.125-200 ng/mL.
Molecular Weight
17 kDa
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Features & Benefits
Endotoxin: < 0.01 EU per μg of the protein as determined by the LAL method.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Lyophilized Human IL-1β proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.
Protein Length
The recombinant human IL-1β consists of 154 amino acids and has a predicted molecular mass of 17 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Applications Notes
Human
Other Product Names
IL-1; IL-1 beta; IL-1B; IL1-BETA; IL1F2; Interleukin-1 beta; IL1B
Recommended Usage
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IL-1β protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions
Preparation
E. coli
Accession Number URL
https://www.uniprot.org/uniprot/P01584
AA Sequence
Amino acid sequence derived from human IL-1β (NP_000567.1) (Ala 117-Ser 269) was expressed.

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