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Human IL-36γ Protein

CAT: 0749-PRP1029-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0749-PRP1029-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9) . IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-κB, and can stimulate the inflammatory response in bronchial epithelial cells.
Description
Human IL-36γ protein, expressed in E. coli
Product Name Alternative
Interleukin 36 GammaInterleukin-1 Homolog 1; Interleukin-1 Epsilon; IL-1RP2; IL-1F9 ; IL-1H1 ; IL1H1; IL1E; Interleukin 1-Related Protein 2 ; Interleukin-36 Gamma; IL1RP2; IL1F9
Gene ID
56300
Accession Number
Q9NZH8
Tag
IL-36γ
Type
Cytokines and proteins
Applications
No tag
Purity
> 98 % as determined by SDS-PAGE
Activity
Testing in progress
Molecular Weight
16.7 kDa
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Features & Benefits
Endotoxin: < 1 EU per µg of the protein as determined by the LAL method.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Lyophilized Human IL-36γ proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.
Protein Length
The recombinant Human IL-36-gamma consists of 152 amino acids and has a predicted molecular mass of 16.7 kDa.
Formulation
Lyophilized from sterile 20 mM tris 50 mM NaCl, pH 6.5.
Applications Notes
Human
Other Product Names
Interleukin 36 GammaInterleukin-1 Homolog 1; Interleukin-1 Epsilon; IL-1RP2; IL-1F9 ; IL-1H1 ; IL1H1; IL1E; Interleukin 1-Related Protein 2 ; Interleukin-36 Gamma; IL1RP2; IL1F9
Recommended Usage
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IL36-gamma protein using the buffer we provided not less than 100 µg/mL, which can then be further diluted to other aqueous solutions.
Preparation
E. coli
Accession Number URL
https://www.uniprot.org/uniprot/Q9NZH8
AA Sequence
Amino acid sequence derived from Human IL-36γ (Q9NZH8) (Ser18-Asp169) was expressed.

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