Recombinant Human IL-1A/IL-1α Protein

• Background:

  Interleukin-1 alpha (IL1α) is a cytokine member of the interleukin-1 family. IL-1 consists of two distinct forms: IL1α and IL1β that recognize the same cell surface receptors but are distinct proteins with approximately 25% amino acid sequence identity. IL1α is constitutively produced by epithelial cells and plays an essential role in maintenance of skin barrier function. Upon stimulation, a wide variety of cells including osteoblasts, monocytes, macrophages can be induced to express IL1α. IL1α possesses a wide range of metabolic, physiological, haematopoietic activities, and is critically involved in the regulation of the immune responses and inflammatory responses.

• Abbreviation:

  IL-1A; IL-1α

• Synonyms:

  IL1F; IL1A; IL-1A; IL1; IL1-ALPHA; IL1F1; BAF; FAF; Hematopoietin 1; Hematopoietin-1; IL 1 alpha; IL 1A; IL1 ALPHA; IL-1 alpha; IL1-A; Interleukin 1 alpha; Interleukin1 alpha; Interleukin-1 alpha; LAF; LEM; Preinterleukin 1 alpha; Pro interleukin 1 alpha; Pro-Interleukin-1-Alpha

• UniProt:

  P01583

• Accession Number:

  P01583

• Expression System:

  E.coli

• Tag:

  C-His

• Sequence:

  Ser113-Ala271

• Applications:

  Cell culture

• Field of Research:

  Immunology; metabolism

• Endotoxin:

  < 0.1 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 98 % as determined by reducing SDS-PAGE.

• Bioactivity:

  501x108IU/ mg.8

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  19 kDa

• Observed Molecular Weight:

  17 kDa

• Species:

  Human