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Human IL-36α Protein

CAT: 0749-PRP1027-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0749-PRP1027-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Human IL-36α previously called IL-1F6 and FIL-1 epsilon (family of IL-1 member epsilon), is a member of the IL-1 family which includes IL-1b, IL-1a, IL-1ra, IL-18, IL-36ra (IL-1F5), IL-36b (IL-1F8), IL-36g (IL-1F9), IL-37 (IL-1F7) and IL-38 (IL-1F10) . IL-36a is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-36a is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines.IL-36 α, β, and gamma all activate NF-kappa B and MAPK pathways in an IL‑1 Rrp2 dependent manner, and induce production of inflammatory cytokines and chemokines such as CXCL8/IL-8. IL-36 α and other family members are overexpressed in psoriatic skin lesions, and transgenic overexpression of IL‑36 α in skin keratinocytes produces epidermal hyperplasia.
Description
Human IL-36α protein, expressed in E. coli
Product Name Alternative
Interleukin-36 Alpha; FIL1 Epsilon; Interleukin-1 Epsilon; IL-1 Epsilon; Interleukin-1 Family Member 6; IL-1F6; IL36A; FIL1E; IL1E; IL1F6
Gene ID
27179
Accession Number
Q9UHA7
Tag
IL-36α
Type
Cytokines and proteins
Applications
No tag
Purity
> 98 % as determined by SDS-PAGE
Activity
Testing in progress
Molecular Weight
17 kDa
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Features & Benefits
Endotoxin: < 0.1 EU per µg of the protein as determined by the LAL method.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Lyophilized Human IL-36α proteinshould be stored desiccated below -18°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.
Protein Length
The recombinant Human IL-36α consists of 153 amino acids and has a predicted molecular mass of 17 KD.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Applications Notes
Human
Other Product Names
Interleukin-36 Alpha; FIL1 Epsilon; Interleukin-1 Epsilon; IL-1 Epsilon; Interleukin-1 Family Member 6; IL-1F6; IL36A; FIL1E; IL1E; IL1F6
Recommended Usage
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IL36 alpha protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Preparation
E. coli
Accession Number URL
https://www.uniprot.org/uniprot/Q9UHA7
AA Sequence
Amino acid sequence derived from Human IL-36α (Q9UHA7) (Lys6-Phe158) was expressed.

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