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QC-01–175

CAT: 0804-HY-134850-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134850-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 ; Black: linker NH2-PEG3 (HY-W007545) ; Blue: ligand for E3 ligase Pomalidomide (HY-10984) )[2].
CAS Number
2267290-96-8
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
PROTACs; Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling; PROTAC
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/qc-01-175.html
Concentration
10mM
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCC4=CC5=C(C=C4)C(C=NC=C6)=C6N5
Molecular Formula
C33H34N6O7
Molecular Weight
626.66
Precautions
H315, H319, H320
References & Citations
[1]Silva MC, et al., Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 2019 Mar 25;8:e45457.|[2]Tiziana Petrozziello, et al. Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2022 Jan;59 (1) :683-702.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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