DL-175

• Description:

  DL-175 (compound 13) is a selective GPR84 agonist with biased agonistic activity. DL-175 can selectively activate functional responses in immune cells and induce enhanced chemotaxis and phagocytosis of human bone marrow cells. DL-175 is a potential chemical probe[1].

• UNSPSC:

  12352005

• Target:

  GPR84

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/dl-175.html

• Purity:

  99.0

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=C2C=CC=CC2=C(OCCC3=C[N+]([O-])=CC=C3)C=C1

• Molecular Formula:

  C17H14ClNO2

• Molecular Weight:

  299.75

• References & Citations:

  [1]Lucy D, et al. A Biased Agonist at Immunometabolic Receptor GPR84 Causes Distinct Functional Effects in Macrophages. ACS Chem Biol. 2019 Sep 20;14 (9) :2055-2064.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2487253-25-6]