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QC-182

CAT: 0804-HY-162259-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-162259-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
QC-182 is a potent PROTAC degrader of p300/CBP. QC-182 reduces p300 protein in the SK-HEP-1 cells (DC50 = 93nM) . QC-182 potently and effectively inhibits cell growth in the SK-HEP-1 and JHH7 cell lines with IC50 values of 0.733 and 0.477 μM, respectively. QC-182 can be used for the research of hepatocellular carcinoma (HCC) [1].
CAS Number
3032646-96-8
UNSPSC
12352005
Target
Histone Acetyltransferase; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/qc-182.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2C(NC(CC2)=O)=O)C(C(C1=C3)=CC=C3N(C4)CC4N5CCC(N6C7=CC=C(C8=C(C)ON=C8C)C=C7N=C6[C@H]9N(C%10=CC(F)=C(F)C=C%10)C(CCC9)=O)CC5)=O
Molecular Formula
C44H42F2N8O6
Molecular Weight
816.85
References & Citations
[1]Chang Q, et al. Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma. J Med Chem. 2024 Feb 22;67 (4) :2466-2486.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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