BSJ-01-175

CAT: 0804-HY-145072-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-145072-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

BSJ-01-175 is a potent and selective CDK12/13 covalent inhibitor. BSJ-01-175 demonstrates exquisite selectivity, potent inhibition of RNA polymerase II phosphorylation, and downregulation of CDK12-targeted genes in cancer cells[1].

CAS Number

2227392-55-2

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bsj-01-175.html

Purity

99.49

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CN=C(N[C@H]2C[C@@H](CCC2)OC3=CC=C(C=C3)NC(/C=C/CN(C)C)=O)N=C1C4=CNC5=CC=CC=C45

Molecular Formula

C30H33ClN6O2

Molecular Weight

545.08

References & Citations

[1]Jiang B, et al. Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma. Eur J Med Chem. 2021;221:113481.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK12; CDK13

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