OYYF-175

• Description :

  OYYF-175, an antimicrobial antifolate, is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.36 nM for Escherichia coli DHFR. OYYF-175 exhibits potent broad-spectrum antibacterial activities, especially against multi-drug resistant Gram-Negative-strains[1].

• CAS Number :

  [65829-22-3]

• UNSPSC :

  12352005

• Target :

  Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/oyyf-175.html

• Solubility :

  10 mM in DMSO

• Smiles :

  NC1=C2C3=C(N(CC4=CC=CC=C4F)C=C3)C=CC2=NC(N)=N1

• Molecular Formula :

  C17H14FN5

• Molecular Weight :

  307.32

• References & Citations :

  [1]Yue Li, et al. The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates. Eur J Med Chem. 2022 Jan 15;228:113979.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported