SE 175

• Description:

  SE 175 is an organic nitrate compound that acts as an NO donor in vivo following reductive transformation of the nitrate group to nitric oxide. SE 175 stimulates endothelial soluble guanylate cyclase and induces aortic vasorelaxation with an EC50 of 0.20 µM[1].

• UNSPSC:

  12352005

• Target:

  Guanylate Cyclase; NO Synthase

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C (OC) C1=CC=CC=C1SC (C2=CC=C (CO[N+] ([O-]) =O) C=C2) =O

• Molecular Formula:

  C16H13NO6S

• Molecular Weight:

  347.34

• References & Citations:

  [1]Endres S, et al. NO-Donors, part 3: nitrooxyacylated thiosalicylates and salicylates - synthesis and biological activities (#) . Eur J Med Chem. 1999;34 (11) :895-901.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  258278-64-7