Anticancer agent 175

• Description :

  Anticancer agent 175 (complex 1) ia a near-infrared (NIR) luminescent theranostic complex. Anticancer agent 175 induces ROS accumulation, mitochondrial damage, disruption of Bax/Bcl-2 equilibrium, and tumor cell apoptosis in HepG2 cell line[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/anticancer-agent-175.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=C2C3=CC=CC=C3[Ir]45([N]6=C7C=C(F)C(F)=CC7=NC(C)=C6C8=CC=CC=C84)([N]9=C%10C=CC=CC%10=C(C(NCCCCCCNC([C@@](C)(CC[C@@]%11(CC[C@@]%12(C%13=CC([C@@]%14([C@]%15(CC[C@@H](C([C@@]%15(CC[C@@]%12%14C)[H])(C)C)O)C)[H])=O)C)C)C[C@]%11%13[H])=O)=O)C=C9C%16=CC=CC=[N]%165)[N]2=C%17C=C(F)C(F)=CC%17=N1.[F-][P+5]([F-])([F-])([F-])([F-])[F-]

• Molecular Formula :

  C81H86F10IrN8O4P-

• Molecular Weight :

  1648.78

• References & Citations :

  [1]Wang L, et al. A glycyrrhetinic acid-iridium (III) conjugate as a theranostic NIR probe for hepatocellular carcinoma with mitochondrial-targeting ability. Eur J Med Chem. Published online November 25, 2023.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [9007-83-4]