IK-175

• Description :

  IK-175 is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. IK-175 effectively blocks AHR from translocating from the cytoplasm to the nucleus. IK-175 is highly selective for AHR over other receptors, transporters, and kinases[1].

• Product Name Alternative :

  AHR antagonist 5 (free base)

• UNSPSC :

  12352005

• Target :

  Aryl Hydrocarbon Receptor

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ahr-antagonist-5-free-base.html

• Purity :

  99.78

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(C)C(C=N1)=C2N1C(N[C@H]3CC4=C(CC3)NC5=CC=CC=C45)=NC(C6=CN=CC(F)=C6)=N2

• Molecular Formula :

  C25H24FN7

• Molecular Weight :

  441.50

• References & Citations :

  [1]Marta Sanchez-Martin, et al. Ahr inhibitors and uses thereof. WO2021142180A1.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [2247950-42-9]