IK-175

• Description:

  IK-175 is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. IK-175 effectively blocks AHR from translocating from the cytoplasm to the nucleus. IK-175 is highly selective for AHR over other receptors, transporters, and kinases[1].

• Product Name Alternative:

  AHR antagonist 5 (free base)

• UNSPSC:

  12352005

• Target:

  Aryl Hydrocarbon Receptor

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ahr-antagonist-5-free-base.html

• Purity:

  99.78

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC (C) C (C=N1) =C2N1C (N[C@H]3CC4=C (CC3) NC5=CC=CC=C45) =NC (C6=CN=CC (F) =C6) =N2

• Molecular Formula:

  C25H24FN7

• Molecular Weight:

  441.50

• References & Citations:

  [1]Marta Sanchez-Martin, et al. Ahr inhibitors and uses thereof. WO2021142180A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  2247950-42-9