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CDK2 degrader 3

CAT: 0804-HY-164827-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164827-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK2 degrader 3 can selectively degrade CDK2 and has anti-tumor activity[1].
CAS Number
2862772-71-0
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk2-degrader-3.html
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N(C2CCCC2)C3=NC(NC4=C(C=C(C=C4)S(NCCO[C@H]5CC[C@@H](CC5)CN6CCC(C7=CC8=NC=C(N9C(NC(CC9)=O)=O)N8C=C7)CC6)(=O)=O)C)=NC=C3C=C1Cl
Molecular Formula
C44H53ClN10O6S
Molecular Weight
885.47
References & Citations
[1]Nicholas Kwiatkowski, et al. CDK2 Heterobifunctional Degraders Co-Degrade CDK2 and Cyclin E Resulting in Efficacy in CCNE1-Amplified and Overexpressed Cancers. KYMERA. 2024.OCTOBER 23.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2

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