CDK2 degrader 5

• Description:

  CDK2 degrader 5 (compound 12) is a degrader for CDK2, with the Dmax of >50% and ≤80% in HiBiT Assay. CDK2 degrader 5 plays an important role in cancer research[1].

• UNSPSC:

  12352005

• Target:

  CDK

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Purity:

  99.17

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(NCC1=CC=C2C(C(N(C3C(NC(CC3)=O)=O)C2)=O)=C1)OCC4=CC=CC(C5=CC=CC=C5)=C4C

• Molecular Formula:

  C29H27N3O5

• Molecular Weight:

  497.54

• References & Citations:

  [1]Monte Rosa Therapeutics, Inc. Preparation of 3- (6-substituted-1-oxoisoindolin-2-yl) piperidine-2,6-dione derivatives that mediate the degradation of cyclin-dependent kinase (CDK2) and are useful in the treatment of various disorders, such as cancer. World Intellectual Property Organization, WO2023069700 A1 2023-04-27

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK2

• CAS Number:

  [2923574-11-0]