CDK2 degrader 2

• CAS Number:

  3030271-16-7

• UNSPSC Description:

  CDK2 degrader 2 is a PROTAC class CDK2 degrader. The CDK2 binding moiety (CBM) binds to the CDK2 protein and subsequently undergoes ubiquitination, leading to the degradation of CDK2 through the ubiquitin proteasome pathway (UPP). CDK2 degrader 2 can cause degradation of CDK2 in MKN1 cells, with a DC50 value less than 100 nM and an average Dmax value greater than 75%. (Red: CBM; Blue: DIM; Black: linker)

• Target Antigen:

  CDK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/cdk2-degrader-2.html

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C1C(Cl)=CC2=C(N1C(C)C)N=C(NC3=CC=C(S(=O)(C4CCN(C5CCN(CC6CCN(CC6)C7=C(N(C)C(N8C9C(NC(CC9)=O)=O)=O)C8=CC=C7)CC5)CC4)=O)C=C3C)N=C2

• Molecular Weight:

  913.53

• References & Citations:

  [1] Collier, Philip, et al. CDK2 DEGRADERS AND USES THEREOF. US, US20240173419A1. 2024-05-30.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported