CDK2 degrader 6

• Description:

  CDK2 degrader 6 (compound 6) is an orally active and potent CDK2 molecular glue degrader with a DC50 of 46.5 nM. CDK2 degrader 6 can be used in the study of breast cancer[1].

• UNSPSC:

  12352005

• Target:

  CDK; Molecular Glues

• Related Pathways:

  Cell Cycle/DNA Damage; PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Purity:

  99.81

• Smiles:

  O=C(C(CC1)C2=C(F)C=C(N3C[C@H](NC4=NN=C(C56CC(C6)(C(F)(F)F)C5)O4)[C@H]3C)C=C2F)NC1=O

• Molecular Formula:

  C23H22F5N5O3

• Molecular Weight:

  511.44

• References & Citations:

  [1]Andreas RITZÉN, et al. Compounds that mediate protein degradation and methods of use thereof. WO2025090727A1. 2025-05-01.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3036606-92-2]