PROTAC CDK2 Degrader-1

PROTAC CDK2 Degrader-1

• CAS Number: 3024971-78-3
• UNSPSC Description: PROTAC CDK2 Degrader-1 (Compound 41) is a PROTAC degrader for cyclin-dependent kinase 2 (CDK2). PROTAC CDK2 Degrader-1 inhibits the phosphorylation of RB protein in CDK2 dependent cell line OVCAR3 with an IC50 of 100-500 nM[1].
• Target Antigen: CDK; PROTACs
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;PROTAC
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-cdk2-degrader-1.html
• Smiles: CN1C2=CC(C3CCN(CC4CCN(S(N5CCC(NC6=NC(C7=CN(CC(F)(F)F)N=C7)=C(C(F)(F)F)C=N6)CC5)(=O)=O)CC4)CC3)=CC=C2C(N8CCC(NC8=O)=O)=N1
• Molecular Weight: 880.91
• References & Citations: [1]Yu Z, et al., Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 via ubiquitin proteasome pathway. WO2024102849
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported