PROTAC CDK2 Degrader-1

• UNSPSC Description:

  PROTAC CDK2 Degrader-1 (Compound 41) is a PROTAC degrader for cyclin-dependent kinase 2 (CDK2). PROTAC CDK2 Degrader-1 inhibits the phosphorylation of RB protein in CDK2 dependent cell line OVCAR3 with an IC50 of 100-500 nM[1].

• Target Antigen:

  CDK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-cdk2-degrader-1.html

• Smiles:

  CN1C2=CC(C3CCN(CC4CCN(S(N5CCC(NC6=NC(C7=CN(CC(F)(F)F)N=C7)=C(C(F)(F)F)C=N6)CC5)(=O)=O)CC4)CC3)=CC=C2C(N8CCC(NC8=O)=O)=N1

• Molecular Weight:

  880.91

• References & Citations:

  [1]Yu Z, et al., Bifunctional compounds containing 2,5-substituted pyrimidine derivatives for degrading cyclin-dependent kinase 2 via ubiquitin proteasome pathway. WO2024102849

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3024971-78-3