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CDK2 degrader 2

CAT: 0931-T89344-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89344-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3030271-16-7
Bioactivity
CDK2 degrader2 is a PROTAC class CDK2 degrader that targets the CDK2 protein for ubiquitination, facilitating its degradation via the ubiquitin-proteasome pathway (UPP) . It effectively degrades CDK2 in MKN1 cells, with a DC50 value of less than 100 nM and an average Dmax greater than 75%.
Smiles
O=C1C(Cl)=CC=2C=NC(=NC2N1C(C)C)NC3=CC=C(C=C3C)S(=O)(=O)C4CCN(CC4)C5CCN(CC5)CC6CCN(C=7C=CC=C8C7N(C(=O)N8C9C(=O)NC(=O)CC9)C)CC6
Molecular Formula
C46H57ClN10O6S
Molecular Weight
913.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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