CDK2 degrader 2

• Bioactivity:

  CDK2 degrader2 is a PROTAC class CDK2 degrader that targets the CDK2 protein for ubiquitination, facilitating its degradation via the ubiquitin-proteasome pathway (UPP) . It effectively degrades CDK2 in MKN1 cells, with a DC50 value of less than 100 nM and an average Dmax greater than 75%.

• Smiles:

  O=C1C(Cl)=CC=2C=NC(=NC2N1C(C)C)NC3=CC=C(C=C3C)S(=O)(=O)C4CCN(CC4)C5CCN(CC5)CC6CCN(C=7C=CC=C8C7N(C(=O)N8C9C(=O)NC(=O)CC9)C)CC6

• Molecular Formula:

  C46H57ClN10O6S

• Molecular Weight:

  913.53

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3030271-16-7