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CDK2-IN-18

CAT: 0804-HY-155602Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155602Size:1 Each
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Description
CDK2-IN-18 (compound 8q) is a potent inhibitor of CDK2/E and CDK4/D1, with IC50s of 8 nM and 46 nM, respectively. CDK2-IN-18 inhibits the proliferation of tumor cells[1].
CAS Number
364735-73-9
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk2-in-18.html
Solubility
10 mM in DMSO
Smiles
O=C(NN1CCN(CC1)C)NC2=CC=CC(C3=NNC(C4=C(C)N=C(C)S4)=C35)=C2C5=O
Molecular Formula
C21H23N7O2S
Molecular Weight
437.52
References & Citations
[1]Eddy W Yue, et al. Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3. Bioorg Med Chem Lett. 2004 Jan 19;14 (2) :343-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK4

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