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CDK2-IN-22

CAT: 0804-HY-157516-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-157516-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK2-IN-22 (compound 7I) is a potent CDK2 inhibitor with an IC50 of 64.42 nM. CDK2-IN-22 presents a broad antiproliferative efficacy toward diverse cancer cells MV4-11, HT-29, MCF-7, and HeLa with IC50 values of 0.83 μM, 2.12 μM, 3.12 μM, and 8.61 μM, respectively[1].
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk2-in-22.html
Purity
98.64
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(NC2=NC=CC(NC3=CC(OC4=CC=CC=C4)=CN=C3)=N2)C=C1)(N)=O
Molecular Formula
C21H18N6O3S
Molecular Weight
434.47
References & Citations
[1]Wen-Bin Zeng, et al. Design, synthesis, and biological evaluation of N- (pyridin-3-yl) pyrimidin-4-amine analogues as novel cyclin-dependent kinase 2 inhibitors for cancer therapy. Bioorg Chem. 2024 Feb:143:107019.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2

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