CDK9-IN-18

CAT: 0804-HY-147905Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-147905Size:1 Each
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Description
CDK9-IN-18 is a potent CDK9 inhibitor. CDK9-IN-18 blocks the phosphorylation function of kinase CDK9. CDK9-IN-18 exhibits both good anticancer activity and low cellular activity. CDK9-IN-18 induces apoptosis.
CAS Number
[1804127-83-0]
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk9-in-18.html
Solubility
10 mM in DMSO
Smiles
O=C(C(N1)=CC2=C1C=CC(NC3=NC=CC(C4=CC=CN=C4)=N3)=C2)N/N=C/C5=CNC6=C5C=CC=C6
Molecular Formula
C27H20N8O
Molecular Weight
472.50
References & Citations
[1]Hu H, et al. Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5- ((4- (pyridin-3-yl) pyrimidin-2-yl) amino) -1H-indole scaffold: Novel potential CDK9 inhibitors. Bioorg Chem. 2020 Sep;102:104064.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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