BIO-8169

• Target:

  IRAK

• Related Pathways:

  NF-?B|||Immunology/Inflammation

• Bioactivity:

  BIO-8169, a selective interleukin receptor-associated kinase 4 (IRAK 4) inhibitor, demonstrates potent activity with an IC 50 value of 0.23 nM. Exhibiting strong pharmacokinetic properties, BIO-8169 effectively reduces pro-inflammatory cytokine production and mitigates autoimmune encephalomyelitis in the EAE mouse model. Additionally, it has notable blood-brain penetration, evidenced by a rat Kpu, u of 0.7.

• Smiles:

  O=C(NC1=CC=CN(C1=O)C2CC2)C3=CN4C=C(N=C4N=C3OC(C)C)C56COC(C)(C5)C6

• Molecular Formula:

  C24H27N5O4

• Molecular Weight:

  449.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2792153-06-9