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BIO-8169

CAT: 0931-T87972-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T87972-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2792153-06-9
Target
IRAK
Related Pathways
NF-?B|||Immunology/Inflammation
Bioactivity
BIO-8169, a selective interleukin receptor-associated kinase 4 (IRAK 4) inhibitor, demonstrates potent activity with an IC 50 value of 0.23 nM. Exhibiting strong pharmacokinetic properties, BIO-8169 effectively reduces pro-inflammatory cytokine production and mitigates autoimmune encephalomyelitis in the EAE mouse model. Additionally, it has notable blood-brain penetration, evidenced by a rat Kpu, u of 0.7.
Smiles
O=C(NC1=CC=CN(C1=O)C2CC2)C3=CN4C=C(N=C4N=C3OC(C)C)C56COC(C)(C5)C6
Molecular Formula
C24H27N5O4
Molecular Weight
449.5
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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