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FPI-1523

CAT: 0804-HY-139745ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-139745ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 exhibits considerable antimicrobial activity[1].
CAS Number
1452459-50-5
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/fpi-1523.html
Solubility
10 mM in DMSO
Smiles
CC(NNC([C@H]1[N@@]2C(N([C@H](CC1)C2)OS(=O)(O)=O)=O)=O)=O
Molecular Formula
C9H14N4O7S
Molecular Weight
322.30
References & Citations
[1]King AM, et, al. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chem Biol. 2016 Apr 15;11 (4) :864-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

CID 71682990
CAS Number1452459-50-5
PubChem CID71682990
IUPAC Name[(2S,5R)-2-(acetamidocarbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate
Molecular FormulaC9H14N4O7S
Molecular Weight322.30
XLogP-1.9
Topological Polar Surface Area154
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity571
SMILES
CC(=O)NNC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O
InChI
InChI=1S/C9H14N4O7S/c1-5(14)10-11-8(15)7-3-2-6-4-12(7)9(16)13(6)20-21(17,18)19/h6-7H,2-4H2,1H3,(H,10,14)(H,11,15)(H,17,18,19)/t6-,7+/m1/s1
InChIKey
WVZOCYGRXONJLX-RQJHMYQMSA-N
Chemical Structure
2D Structure
2D structure of CID 71682990
CAS: 1452459-50-5
CID: 71682990
Formula: C9H14N4O7S
MW: 322.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight322.30
XLogP3-1.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass322.05831997
Monoisotopic Mass322.05831997
Topological Polar Surface Area154 Ų
Heavy Atom Count21
Formal Charge0
Complexity571
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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