CJ-15208

CJ-15208

• CAS Number: 210236-47-8
• UNSPSC Description: CJ-15208 is a potent and selective κ-opioid receptor antagonist with significant opioid activity. CJ-15208 exhibited strong analgesic effects in the warm water tail withdrawal test in mice and was mediated through multiple opioid receptors. The stereoisomers of CJ-15208 exhibited different opioid activity characteristics, for example, one stereoisomer exhibited κ-opioid receptor antagonism, while the other exhibited δ-opioid receptor antagonism. All stereoisomers of CJ-15208 had no significant effects on respiration. The stereoisomers of CJ-15208 did not lead to the development of drug tolerance, which makes it potential in the further development of safe opioid analgesics[1].
• Target Antigen: Opioid Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/cj-15208.html
• Smiles: O=C(N[C@H](C(N1[C@@](CCC1)([H])C(N[C@H](C(N2)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)[C@@H]2CC5=CNC6=CC=CC=C56
• Molecular Weight: 577.67
• References & Citations: [1]Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported