Progranulin modulator-1

Progranulin modulator-1

• CAS Number: 2641013-11-6
• UNSPSC Description: Progranulin modulator-1 (Compound 60) is an orally active enhancer of progranulin (PGRN) secretion. Progranulin modulator-1 enhances the potency of BV-2 cell to increase PGRN levels, has inhibitory effect on hERG and Low cytotoxicity, the PGRN EC50 and hERG IC50 were 83 and 3100 nM, respectively[1].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/progranulin-modulator-1.html
• Solubility: 10 mM in DMSO
• Smiles: FC1=CC=C(C=C1)[C@@H]2N(C3=N[C@H](C4(CNC4)F)CO3)CCC5=CC=CC=C52
• Molecular Weight: 369.41
• References & Citations: [1]Peng X, et al. Discovery of oxazoline enhancers of cellular progranulin release. Bioorg Med Chem Lett. 2023 Jan 15;80:129048.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported