Progranulin modulator-1

CAT: 0931-T87248-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T87248-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2641013-11-6
Target
Others|||TNF
Related Pathways
Apoptosis|||Others
Bioactivity
Progranulin Modulator-1 (Compound 60) is an orally active compound that promotes progranulin (PGRN) secretion. It enhances the ability of BV-2 cells to elevate PGRN levels, exhibits low cytotoxicity, and possesses an inhibitory effect on hERG. The EC50 for PGRN is 83 nM, and the IC50 for hERG is 3100 nM [1].
Smiles
FC1=CC=C([C@@H]2N(CCC=3C2=CC=CC3)C4=N[C@@H](CO4)[C@@]5(F)CNC5)C=C1
Molecular Formula
C21H21F2N3O
Molecular Weight
369.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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