Progranulin modulator-1

• Target:

  Others|||TNF

• Related Pathways:

  Apoptosis|||Others

• Bioactivity:

  Progranulin Modulator-1 (Compound 60) is an orally active compound that promotes progranulin (PGRN) secretion. It enhances the ability of BV-2 cells to elevate PGRN levels, exhibits low cytotoxicity, and possesses an inhibitory effect on hERG. The EC50 for PGRN is 83 nM, and the IC50 for hERG is 3100 nM [1].

• Smiles:

  FC1=CC=C([C@@H]2N(CCC=3C2=CC=CC3)C4=N[C@@H](CO4)[C@@]5(F)CNC5)C=C1

• Molecular Formula:

  C21H21F2N3O

• Molecular Weight:

  369.41

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2641013-11-6