Progranulin modulator-2

• UNSPSC Description:

  Progranulin modulator-2 (compound 18A) is a bromodomain and extra-terminal domain (BET) inhibitor. Progranulin modulator-2 enhances PGRN expression by targeting members of the BET protein family. Progranulin modulator-2 can be used to study the role of BET protein in neurodevelopment, neuroplasticity and neurodegeneration[1].

• Target Antigen:

  Epigenetic Reader Domain

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/progranulin-modulator-2.html

• Smiles:

  O=C1C(NC=C2)=C2C(C3=CC=CN=C3OC4=CC=C(F)C=C4)=CN1C

• Molecular Weight:

  335.33

• References & Citations:

  [1]Rosenthal Z C, et al. Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia[J]. Scientific reports, 2024, 14(1): 9064.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported