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Progranulin modulator-2

CAT: 0804-HY-163543Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163543Size:1 Each
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Description
Progranulin modulator-2 (compound 18A) is a bromodomain and extra-terminal domain (BET) inhibitor. Progranulin modulator-2 enhances PGRN expression by targeting members of the BET protein family. Progranulin modulator-2 can be used to study the role of BET protein in neurodevelopment, neuroplasticity and neurodegeneration[1].
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/progranulin-modulator-2.html
Smiles
O=C1C(NC=C2)=C2C(C3=CC=CN=C3OC4=CC=C(F)C=C4)=CN1C
Molecular Formula
C19H14FN3O2
Molecular Weight
335.33
References & Citations
[1]Rosenthal Z C, et al. Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia[J]. Scientific reports, 2024, 14 (1) : 9064.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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