PROTAC GSPT1 degrader-2

PROTAC GSPT1 degrader-2

• CAS Number: 3024909-61-0
• UNSPSC Description: PROTAC GSPT1 degrader-2 (compound A) is a GSPT1 molecule glue with more than 95% degradation. GSPT1 degrader-8 inhibits cell viability in HL-60 cells with an IC50 of 10 nM[1].
• Target Antigen: Molecular Glues
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-gspt1-degrader-2.html
• Smiles: O=C1NC(C(CC1)N2C(C3=CC=C(N4CCC(CC4)CN5C(N(CCC5)C6=CC(C7=C(Cl)C8=C(NC=C8CC)N=C7)=CC=C6)=O)C=C3C2=O)=O)=O
• Molecular Weight: 708.21
• References & Citations: [1]Lichao FANG, et al. Gspt1 degraders, compositions comprising the degrader, and methods of using the same. French, WO2024073871A1. 2024-04-11
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported