PROTAC HPK1 Degrader-2

• UNSPSC Description:

  PROTAC HPK1 Degrader-2 (compound 3) is a PROTAC degrader of HPK1, with the DC50 of 23 nM in human PBMC. PROTAC HPK1 Degrader-2 plays an important role in cancer research[1].

• Target Antigen:

  MAP4K; PROTACs

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-hpk1-degrader-2.html

• Smiles:

  CC1=C2C(CCN(CCC(N3CCN(C4=CC=C(N5C(NC(CC5)=O)=O)C=C4)CC3)=O)C2)=CC(C6=NC(C(C7=CC=C(C(N(C)C)=O)C(C)=C7)=CN8)=C8N=C6)=C1

• Molecular Weight:

  753.89

• References & Citations:

  [1]BeiGene, Ltd. Preparation of pyrrolo[2,3-b]pyrazine-based bifunctional compounds as HPK1 degraders and the use thereof. World Intellectual Property Organization, WO2023006063 A1 2023-02-02.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2893885-31-7