PROTAC HPK1 Degrader-2

PROTAC HPK1 Degrader-2

• CAS Number: 2893885-31-7
• UNSPSC Description: PROTAC HPK1 Degrader-2 (compound 3) is a PROTAC degrader of HPK1, with the DC50 of 23 nM in human PBMC. PROTAC HPK1 Degrader-2 plays an important role in cancer research[1].
• Target Antigen: MAP4K; PROTACs
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-hpk1-degrader-2.html
• Smiles: CC1=C2C(CCN(CCC(N3CCN(C4=CC=C(N5C(NC(CC5)=O)=O)C=C4)CC3)=O)C2)=CC(C6=NC(C(C7=CC=C(C(N(C)C)=O)C(C)=C7)=CN8)=C8N=C6)=C1
• Molecular Weight: 753.89
• References & Citations: [1]BeiGene, Ltd. Preparation of pyrrolo[2,3-b]pyrazine-based bifunctional compounds as HPK1 degraders and the use thereof. World Intellectual Property Organization, WO2023006063 A1 2023-02-02.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported