PROTAC eDHFR Degrader-2

PROTAC eDHFR Degrader-2

• CAS Number: 2849442-91-5
• UNSPSC Description: PROTAC eDHFR Degrader-2 (compound 7b) is a potent degrader targeting Escherichia coli dihydrofolate reductase (eDHFR), enabling robust degradation of eDHFR-tagged proteins[1].
• Target Antigen: Bacterial; PROTACs
• Type: Reference compound
• Related Pathways: Anti-infection;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/protac-edhfr-degrader-2.html
• Solubility: 10 mM in DMSO
• Smiles: NC1=C(CC2=CC(OC)=C(OCCCC(NCCOCCNC3=C(C(N(C4C(NC(CC4)=O)=O)C5=O)=O)C5=CC=C3)=O)C(OC)=C2)C=NC(N)=N1
• Molecular Weight: 704.73
• References & Citations: [1]Etersque JM et al. Regulation of eDHFR-tagged proteins with trimethoprim PROTACs. Nat Commun. 2023 Nov 3;14(1):7071.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported