PROTAC eDHFR Degrader-2

• UNSPSC Description:

  PROTAC eDHFR Degrader-2 (compound 7b) is a potent degrader targeting Escherichia coli dihydrofolate reductase (eDHFR), enabling robust degradation of eDHFR-tagged proteins[1].

• Target Antigen:

  Bacterial; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-edhfr-degrader-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=C(CC2=CC(OC)=C(OCCCC(NCCOCCNC3=C(C(N(C4C(NC(CC4)=O)=O)C5=O)=O)C5=CC=C3)=O)C(OC)=C2)C=NC(N)=N1

• Molecular Weight:

  704.73

• References & Citations:

  [1]Etersque JM et al. Regulation of eDHFR-tagged proteins with trimethoprim PROTACs. Nat Commun. 2023 Nov 3;14(1):7071.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2849442-91-5