PROTAC GSPT1 degrader-1

PROTAC GSPT1 degrader-1

• CAS Number: 3034310-17-0
• UNSPSC Description: PROTAC GSPT1 degrader-1 (Compound F) is a PROTAC degrader for G1 to S phase transition protein 1 (GSPT1) that degrades GSPT1 with a rate of 95% (1 μM) GSPT1 and 86% (0.1 μM). PROTAC GSPT1 degrader-1 inhibits the cell viability of HL-60 with an IC50 of 9.2 nM. (Pink: ligand for target protein (HY-W599025); Black: linker (HY-159619); Blue: ligand for E3 ligase (HY-W087383))[1]
• Target Antigen: PROTACs
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-gspt1-degrader-1.html
• Smiles: O=C1NC(C(CC1)N2C(C3=CC=C(N4CC(CCN5C(N(CCC5)C6=CC(C7=C(Cl)C8=C(NC=C8CC)N=C7)=CC=C6)=O)C4)C=C3C2=O)=O)=O
• Molecular Weight: 694.18
• References & Citations: [1]Fang Li, et al., Gspt1 degraders, compositions comprising the degrader, and methods of using the same. WO2024073871A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported