PROTAC GSPT1 degrader-1

• CAS Number:

  3034310-17-0

• UNSPSC Description:

  PROTAC GSPT1 degrader-1 (Compound F) is a PROTAC degrader for G1 to S phase transition protein 1 (GSPT1) that degrades GSPT1 with a rate of 95% (1 μM) GSPT1 and 86% (0.1 μM). PROTAC GSPT1 degrader-1 inhibits the cell viability of HL-60 with an IC50 of 9.2 nM. (Pink: ligand for target protein (HY-W599025); Black: linker (HY-159619); Blue: ligand for E3 ligase (HY-W087383))[1]

• Target Antigen:

  PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-gspt1-degrader-1.html

• Smiles:

  O=C1NC(C(CC1)N2C(C3=CC=C(N4CC(CCN5C(N(CCC5)C6=CC(C7=C(Cl)C8=C(NC=C8CC)N=C7)=CC=C6)=O)C4)C=C3C2=O)=O)=O

• Molecular Weight:

  694.18

• References & Citations:

  [1]Fang Li, et al., Gspt1 degraders, compositions comprising the degrader, and methods of using the same. WO2024073871A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported