PROTAC IRAK4 degrader-12

• UNSPSC Description:

  PROTAC IRAK4 degrader-12 is a PROTAC based on Cereblon ligand, inducing a maximum degradation rate of IRAK4 of 108.46% in K562 cells with an IC50 value of 4.87 nM ( Structure Note: Pink, IRAK4 inhibitor (HY-168611); Blue, E3 (HY-W733885); Black, linker (HY-168613))[1].

• Target Antigen:

  IRAK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-irak4-degrader-12.html

• Smiles:

  O=C1CCC(C(N1)=O)C2=NOC3=C2C4=C(C(NC(CN5CCN(CC5)C[C@@H]6CC[C@H](CC6)N7C=C(C(C(F)F)=N7)NC(C8=COC(C9=CC(NCC%10CC%10)=NC=C9)=N8)=O)=O)=CC=C4)C=C3.Cl

• Molecular Weight:

  926.41

• References & Citations:

  [1]Jinxia Ling, et al. Preparation method for naphthoisoxazole compound. WO2024199146A1 2024-10-03.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2919995-09-6