PROTAC IRAK4 degrader-12

PROTAC IRAK4 degrader-12

• CAS Number: 2919995-09-6
• UNSPSC Description: PROTAC IRAK4 degrader-12 is a PROTAC based on Cereblon ligand, inducing a maximum degradation rate of IRAK4 of 108.46% in K562 cells with an IC50 value of 4.87 nM ( Structure Note: Pink, IRAK4 inhibitor (HY-168611); Blue, E3 (HY-W733885); Black, linker (HY-168613))[1].
• Target Antigen: IRAK; PROTACs
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;PROTAC
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-irak4-degrader-12.html
• Smiles: O=C1CCC(C(N1)=O)C2=NOC3=C2C4=C(C(NC(CN5CCN(CC5)C[C@@H]6CC[C@H](CC6)N7C=C(C(C(F)F)=N7)NC(C8=COC(C9=CC(NCC%10CC%10)=NC=C9)=N8)=O)=O)=CC=C4)C=C3.Cl
• Molecular Weight: 926.41
• References & Citations: [1]Jinxia Ling, et al. Preparation method for naphthoisoxazole compound. WO2024199146A1 2024-10-03.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported