PROTAC IRAK4 degrader-1

PROTAC IRAK4 degrader-1

• CAS Number: 2360533-90-8
• UNSPSC Description: PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes 20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively[1].
• Target Antigen: IRAK; PROTACs
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-irak4-degrader-1.html
• Purity: 99.72
• Solubility: DMSO : 180 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC=C(N2C=C(NC(C3=COC(C4=CC=NC(NCC5CC5)=C4)=N3)=O)C(C(F)(F)F)=N2)C=C1)NCCCN(C=N6)C=C6CNC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8=O)=O)=CC=C7
• Molecular Weight: 904.85
• References & Citations: [1]Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported