PROTAC IRAK4 degrader-8

• UNSPSC Description:

  PROTAC IRAK4 degrader-8 (Compound 2) is a PROTAC IRAK4 degrader (IC50: 15.5 nM). PROTAC IRAK4 degrader-8 degrades IRAK4 in THP-1 cells (DC50: 1.8 nM)。PROTAC IRAK4 degrader-8 also inhibits L-6 production in human whole blood and LPS-induced human PBMC cells, with IC50s of 246 nM and 2.2 nM respectively[1].

• Target Antigen:

  IRAK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-irak4-degrader-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C(C=C1)=CC(N(CCC2=O)C(N2)=O)=C1Cl)N3CCC(CCN4C[C@H]5CC[C@H](N(N=C6C(F)F)C=C6NC(C7=C(N=C(N8[C@](CO9)([H])C[C@]9([H])C8)C=C%10)N%10N=C7)=O)CC5)(CC4)CC3

• Molecular Weight:

  874.38

• References & Citations:

  [1]Ye Z, et al. Preparation of (pyrazolyl)pyrazolo[1,5-a]pyrimidinyl carboxamide derivatives as IRAK4 degrading agents and its applications. China, CN115710274 A. 2023-02-24.|[2]Ye Zhengqing. IRAK4 degradation agent, preparation method and application thereof. Patent. CN115710274.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2911615-06-8