PROTAC IRAK4 degrader-8

PROTAC IRAK4 degrader-8

• CAS Number: 2911615-06-8
• UNSPSC Description: PROTAC IRAK4 degrader-8 (Compound 2) is a PROTAC IRAK4 degrader (IC50: 15.5 nM). PROTAC IRAK4 degrader-8 degrades IRAK4 in THP-1 cells (DC50: 1.8 nM)。PROTAC IRAK4 degrader-8 also inhibits L-6 production in human whole blood and LPS-induced human PBMC cells, with IC50s of 246 nM and 2.2 nM respectively[1].
• Target Antigen: IRAK; PROTACs
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;PROTAC
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-irak4-degrader-8.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C(C=C1)=CC(N(CCC2=O)C(N2)=O)=C1Cl)N3CCC(CCN4C[C@H]5CC[C@H](N(N=C6C(F)F)C=C6NC(C7=C(N=C(N8[C@](CO9)([H])C[C@]9([H])C8)C=C%10)N%10N=C7)=O)CC5)(CC4)CC3
• Molecular Weight: 874.38
• References & Citations: [1]Ye Z, et al. Preparation of (pyrazolyl)pyrazolo[1,5-a]pyrimidinyl carboxamide derivatives as IRAK4 degrading agents and its applications. China, CN115710274 A. 2023-02-24.|[2]Ye Zhengqing. IRAK4 degradation agent, preparation method and application thereof. Patent. CN115710274.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported