PROTAC IRAK4 degrader-2

PROTAC IRAK4 degrader-2

• CAS Number: 2374122-27-5
• UNSPSC Description: PROTAC IRAK4 degrader-2 (Compound 9) is a PROTAC-based IRAK4 degrader that affords potent IRAK4 degradation with a DC50 in peripheral blood mononuclear cells (PBMCs) cells of 151 nM. PROTAC IRAK4 degrader-2 induce a reduction of IRAK4 protein levels with a DC50 of 36 nM in PBMC cells. PROTAC IRAK4 degrader-2 also leads to the inhibition of multiple cytokines in PBMCs[1].
• Target Antigen: IRAK; PROTACs
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;PROTAC
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/protac-irak4-degrader-2.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=C(C(N)=O)C=C(C(C#CCN2CCC3(CCN(C4=NC=C(C(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)C=N4)CC3)CC2)=CN=C8OC[C@@H]9[C@H](CC)[C@H](F)C(N9)=O)C8=C1
• Molecular Weight: 1086.28
• References & Citations: [1]Joao Nunes, et al. Targeting IRAK4 for Degradation with PROTACs. ACS Med Chem Lett. 2019 Jun 14;10(7):1081-1085.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported